// Mouse events emulation
var dispatchMouseEvent = function(target, var_args) {
  var e = document.createEvent("MouseEvents");
  // If you need clientX, clientY, etc., you can call
  // initMouseEvent instead of initEvent
  e.initEvent.apply(e, Array.prototype.slice.call(arguments, 1));
  target.dispatchEvent(e);
};

dispatchMouseEvent(document.getElementById('dijit_form_TextBox_10'), 'mousedown', true, true);
dispatchMouseEvent(element, 'mousedown', true, true);
dispatchMouseEvent(element, 'click', true, true);
dispatchMouseEvent(element, 'mouseup', true, true);