"Proof connection at SQLAlchemy level, on top of pyodbc." # Test SQLAlchemy connection. Result is 42. # Note parameters in connection string, . import urllib from sqlalchemy import create_engine engine = create_engine('mssql+pyodbc:///?odbc_connect=' + urllib.quote_plus('DRIVER=FreeTDS;SERVER=;PORT=1433;DATABASE=;UID=;PWD=;TDS_Version=8.0;') ) for row in engine.execute('select 6 * 7 as [Result];'): print row.Result